STRIP2 (striatin-interacting protein 2) is a calmodulin-binding scaffolding protein and core component of the STRIPAK (striatin-interacting phosphatase and kinase) complex that regulates cell morphology and cytoskeletal organization 1. The STRIPAK complex controls multiple signaling pathways including Hippo, MAPK, and nuclear receptor signaling, with roles in cell growth, differentiation, apoptosis, and immune regulation 2. In disease pathogenesis, STRIP2 is highly overexpressed in multiple cancers including non-small cell lung cancer (NSCLC), breast cancer, and colorectal cancer, correlating with poor prognosis 3. In LUAD, STRIP2 promotes tumor progression through PI3K/AKT/mTOR/MYC pathway activation and epithelial-mesenchymal transition (EMT) 45. STRIP2 also regulates mRNA stability through interaction with IGF2BP3 in an m6A-dependent manner 6. Additionally, STRIP2 controls vascular smooth muscle cell proliferation and migration via P38-AKT-MMP-2 signaling, implicating it in atherosclerosis 7. Clinically, low STRIP2 expression in osimertinib-resistant LUAD associates with higher immune response and potential benefit from immunotherapy 8. STRIP2 acts as an oncogene in various cancers and represents a potential therapeutic target, though it may also influence placental gene expression in response to prenatal environmental exposures 9.