STRN (striatin) is a calmodulin-binding scaffolding protein that serves as the central organizing component of STRIPAK (striatin-interacting phosphatase and kinase) complexes 1. These complexes lack intrinsic catalytic activity but organize large signaling assemblies that regulate protein phosphorylation through association with protein phosphatase 2A and germinal center kinase III kinases 1. STRN modulates multiple signaling pathways including Hippo, MAPK, and nuclear receptor signaling, with roles in cell growth, differentiation, apoptosis, and cytoskeleton remodeling 1. The protein is preferentially expressed in brain tissue and localizes to dendritic spines, where it participates in dendritic development and postsynaptic signaling 2. In disease contexts, STRN dysfunction contributes to neuroinflammation and ferroptosis during ischemic stroke through regulation of phosphoinositide 3-kinase-AKT-mTOR signaling 3. Additionally, STRN variants influence structural connectivity of white-matter tracts and brain function through effects on neurite elongation and guidance 4. STRN plays significant roles in cardiovascular health through regulation of vascular reactivity and blood pressure, with polymorphisms linked to salt sensitivity 5. Clinically, STRN fusion with anaplastic lymphoma kinase (ALK) drives oncogenesis in multiple cancers including lung, thyroid, and mesenchymal malignancies 567.