SUGCT (succinyl-CoA:glutarate-CoA transferase) is a mitochondrial coenzyme A transferase that plays a crucial role in metabolite recycling by catalyzing the transfer of CoA moieties between dicarboxyl-CoA donors and dicarboxylate acceptors 1. The enzyme displays preference for succinyl-CoA and glutarate-CoA as donors and catalyzes the conversion of glutarate to glutaryl-CoA to prevent renal excretion of glutarate, functioning in lysine and tryptophan degradation pathways 1. SUGCT represents the first characterized eukaryotic type III CoA transferase structure 2. Deficiency in SUGCT causes glutaric aciduria type 3 (GA3), a largely asymptomatic biochemical phenotype characterized by elevated urinary glutarate 3. Beyond metabolic functions, SUGCT contributes to cellular protection against ferroptosis through protein glutarylation, particularly involving Nrf2 glutarylation that promotes antioxidant responses 4. In pathological contexts, SUGCT knockout mice develop age-related metabolic syndrome with gut microbiome dysbiosis, lipid accumulation in kidney and liver, and obesity-related phenotypes 5. The enzyme shows tissue-specific expression patterns, with high expression in healthy proximal tubules that decreases during acute kidney injury, correlating with suppressed mitochondrial function 6. SUGCT inhibitors like valsartan and losartan carboxylic acid have been identified as potential therapeutic targets for glutaric aciduria type 1 1.