SYN2 (synapsin II) is a neuronal phosphoprotein localized to chromosome 3 that functions as a key regulator of synaptic vesicle dynamics and neurotransmitter release. SYN2 coats synaptic vesicles and binds to the cytoskeleton, playing critical roles in synaptic vesicle clustering, synapse organization, and chemical synaptic transmission. At the molecular level, SYN2 exhibits ATP binding capacity and facilitates protein-protein interactions essential for synaptic homeostasis 1. Clinically, SYN2 has emerged as a significant disease-associated gene with pleiotropic effects. Loss-of-function mutations in SYN2 (nonsense and missense variants) predispose to autism spectrum disorders, particularly in males, with female carriers remaining unaffected, suggesting sex-limited autosomal expression 1. SYN2 has been identified as a hub gene and therapeutic target in Alzheimer's disease pathogenesis, with computational studies indicating that compounds like lorediplon exhibit favorable binding interactions with SYN2 2. Additionally, SYN2 serves as a marker gene for early AD synaptic abnormality subtypes characterized by dysfunctional synaptic signaling 3. However, SYN2 genetic variants are not significantly associated with epilepsy susceptibility 4, despite functional overlap with SYN1 in regulating neurotransmitter release.