SYT1 encodes synaptotagmin 1, a calcium sensor protein that plays critical roles in synaptic transmission and cellular membrane dynamics. The protein primarily functions as a calcium-dependent regulator of synaptic vesicle exocytosis, where it competes with non-calcium-binding synaptotagmin 11 for membrane binding sites 1. SYT1 exhibits dual-regional lipid-binding through a lysine-rich motif for calcium-independent binding and calcium-binding loops for calcium-facilitated membrane insertion 1. Beyond synaptic function, SYT1 regulates migrasome formation, with its calcium-binding ability being essential for initiating migrasome nucleation and triggering the sequential recruitment of tetraspanins for stabilization 2. The protein also contributes to synaptic plasticity recovery following ischemic stroke, with therapeutic interventions upregulating SYT1 expression alongside other synaptic proteins to improve neuronal transmission efficiency 3. Additionally, SYT1 has been identified as a potential biomarker associated with malignant cell proliferation in glioblastoma 4. Mutations in SYT1 are associated with Baker-Gordon syndrome and childhood-onset chorea 5, highlighting its clinical significance in neurological disorders.