2 sources retrieved · Most recent: April 2026 · Index updated 16 days ago
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27PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
protein secretionmembranerenal osteodystrophythrombophiliaosteoarthritisperipheral vascular disease
Based on limited published evidence, TANGO6 is annotated with a role in protein secretion according to GO terms. TANGO6 is located downstream of CDH1 and contains regulatory elements that form part of a chr16 network controlling CDH1 expression 1. Additionally, differential DNA methylation at TANGO6 has been associated with physical neglect in childhood trauma within a severe mental illness cohort 2. The functional significance of TANGO6 itself remains largely uncharacterized beyond these regulatory and epigenetic associations.
1
TANGO6 lies downstream of CDH1 in a regulatory region that forms part of a chromatin network controlling CDH1 expression and influences cell adhesion and signaling pathways
PMID: 372497502
Differential DNA methylation at TANGO6 is associated with physical neglect in childhood trauma among patients with severe mental illness
PMID: 35501310⚠Limited data available — This gene has 2 indexed publications. Summary and analysis may be incomplete.
renal osteodystrophyOpen Targets
thrombophiliaOpen Targets
osteoarthritisOpen Targets
peripheral vascular diseaseOpen Targets
kidney diseaseOpen Targets
myoepithelial tumorOpen Targets
secondary malignant neoplasmOpen Targets
cutaneous melanomaOpen Targets
colorectal cancerOpen Targets
smoking initiationOpen Targets
cervical carcinomaOpen Targets
gastric cancerOpen Targets
cerebral creatine deficiency syndromeOpen Targets
signet ring cell carcinomaOpen Targets
No pathogenic variants reported on ClinVar for this gene.