TVP23A (trans-golgi network vesicle protein 23 homolog A) is a Golgi membrane protein involved in vesicle-mediated transport and protein secretion. As a member of the trans-Golgi network vesicle protein family, TVP23A localizes to the Golgi apparatus where it functions in protein trafficking and secretory pathway regulation. Clinically, TVP23A has emerged as a candidate gene in neurological disease genetics. It was identified among 26 novel candidate genes for late-onset Parkinson's disease through family-based whole exome analysis, with disrupting variants showing significant excess in affected patients compared to controls 1. Notably, the co-inheritance of multiple rare variants in TVP23A and related genes may predict Parkinson's disease occurrence in approximately 20% of patients with high specificity 1. Beyond neurodegeneration, TVP23A expression is dysregulated in chr16 endometritis, a persistent inflammatory condition affecting fertility. Exceptionally, TVP23A was upregulated in the majority of chr16 endometritis cases regardless of inflammatory cell infiltration severity, suggesting it reflects endometrial cell-type-specific pathophysiology rather than inflammatory accumulation alone 2. Additionally, genetic variants near TVP23A show pleiotropic associations with amino acid digestibility traits in pigs, suggesting roles in nutrient metabolism 3. These findings indicate TVP23A functions in trafficking-dependent processes relevant to neurological homeostasis, reproductive tissue inflammation, and metabolic regulation.