TAS1R2 is a class C G-protein-coupled receptor that functions as a sweet taste receptor by forming a heterodimer with TAS1R3 1. The receptor contains a large extracellular N-terminal domain that serves as the primary binding site for diverse sweet compounds including natural sugars, artificial sweeteners, and plant aroma compounds, while the transmembrane domain binds select sweeteners 23. Structurally, TAS1R2 adopts an asymmetric heterodimer architecture with ligand-induced conformational changes mediating signal transduction 1. Beyond taste perception, TAS1R2 functions as a peripheral glucose sensor in skeletal muscle, regulating NAD homeostasis through ERK1/2-dependent PARP1 activation 4. This extra-gustatory role is clinically significant: muscle-specific TAS1R2 deletion enhances mitochondrial capacity, increases muscle mass and strength, and improves endurance in both normal and obese/aged mice 5. In humans, genetic variation at rs12033832 in TAS1R2 associates with sucrose taste perception and sugar intake in a BMI-dependent manner 6, while loss-of-function variants (rs35874116) correlate with improved muscle phenotypes in obese older individuals 5. These findings establish TAS1R2 as both a chemosensory receptor and a metabolic regulator, positioning it as a potential therapeutic target for muscle health preservation.