Based on limited published evidence, TBC1D19 is predicted to function as a GTPase-activating protein for Rab family proteins and plays a role in protein binding and cilium assembly regulation. TBC1D19 functions in cell polarity; reduced expression disrupts odontoblast polarization and contributes to apoptosis 1. TBC1D19 is identified as a core gene involved in regulating early brain development, with involvement in prenatal dorsolateral prefrontal cortex, inferior parietal cortex, and ventrolateral prefrontal cortex development 2.