TBCA (tubulin folding cofactor A) is a tubulin-binding protein involved in the early steps of tubulin folding and the post-chaperonin tubulin folding pathway 1. TBCA functions as part of the TBCE/TBCB+TBCA system to recycle tubulin heterodimers by receiving β-tubulin from the dissociation of pre-existing heterodimers, thereby controlling free tubulin heterodimer concentration and microtubule dynamics 1. In cancer biology, TBCA promotes clear cell renal cell carcinoma progression, invasion, and metastasis through modulation of cytoskeleton integration and cell cycle regulation 2. Clinically, TBCA has emerged as a significant biomarker in neurodegenerative diseases. Higher plasma TBCA levels are associated with lower Alzheimer's disease (AD) risk 3, and TBCA is dysregulated in preclinical AD, particularly in an APOE-ε4-dependent manner where APOE-ε4 downregulates TBCA yet AD upregulates it 4. Notably, TBCA was nominated as a putative resilience gene that genetically protects individuals from Parkinson's disease despite high genetic risk burden 5. Additionally, TBCA was identified among proteins enriched by SGLT2 inhibitors in heart failure, contributing to enhanced mitochondrial health and ATP production 6. These findings suggest TBCA's involvement in both pathological and protective mechanisms across multiple neurodegenerative and cardiovascular conditions.