TBCCD1 is a centrosomal protein that serves as a key regulator of centrosome and Golgi apparatus positioning, with important consequences for cell organization and function. TBCCD1 localizes to the centrosome, spindle midzone, midbody, and basal bodies of cilia 1. Mechanistically, TBCCD1 maintains the spatial relationship between the centrosome and nucleus, and coordinates Golgi apparatus organization through modulation of microtubule cytoskeleton dynamics 12. Loss of TBCCD1 causes centrosome-nucleus dissociation, Golgi disorganization, increased cell size, reduced primary cilia assembly efficiency, and impaired cell migration in wound-healing assays 1. Notably, TBCCD1 depletion does not affect the major microtubule-nucleating capacity of the centrosome itself 1. TBCCD1's role in centrosome positioning is evolutionarily conserved, with orthologs maintaining centriole linkage in algae and nucleus-centrosome-Golgi linkage in mammalian cells 2. Clinically, gain-of-function alterations in TBCCD1 have been identified as candidates associated with centrosome amplification in human cancers 3, suggesting potential involvement in cancer progression. The protein's function extends to parasitic interactions, where modulation of TBCCD1 levels affects pathogen replication capacity 4.