PALM2AKAP2 is a fusion protein located on chromosome 9 that functions as a scaffolding protein for protein kinase A signaling. The protein binds to the regulatory subunit (RII) of PKA and modulates actin cytoskeleton structure, suggesting roles in establishing polarity in signaling systems and integrating PKA-RII isoforms with downstream effectors to capture and focus cAMP-mediated signals. PALM2AKAP2 localizes to the plasma membrane and exhibits protein-binding capacity 1. Regarding disease relevance, PALM2AKAP2 expression is regulated by TGF-β signaling in triple negative breast cancer, with expression upregulation predicted to be controlled by miR-1275 downregulation 2. In primary Sjögren's syndrome, alternative splicing events in PALM2AKAP2 significantly correlate with disease severity and laboratory indicators, suggesting potential biomarker utility 3. Additionally, PALM2AKAP2 was identified as a potential biomarker for response to MS-275, a histone deacetylase inhibitor, showing upregulation in responsive colon cancer models 4. Clinically, PALM2AKAP2 was identified as a novel locus influencing height variation in Korean populations 1, and a 9q31.2 microdeletion near PALM2AKAP2 was documented in Kallmann syndrome cases, though the deletion did not suppress PALM2AKAP2 expression 5. These findings indicate PALM2AKAP2's involvement in multiple physiological and pathological processes.