BRWD1 — bromodomain and WD repeat domain containing 1

5 sources retrieved · Most recent: April 2026 · Index updated 3 months ago

53PubMed Papers

#8,463 · top 44% of 19K genes

21Diseases

top 19%

0Drugs

2Pathogenic Variants

top 80%

OMIM Disease GeneExperimental GO EvidenceSwiss-Prot Reviewed

nucleolusmotile ciliumaxonemenucleusciliary dyskinesia, primary, 51primary ciliary dyskinesiaatrial fibrillationatrial flutter

AI Summary

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bromodomain and WD repeat domain containing 1

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.

Disease Associations21

ciliary dyskinesia, primary, 51Open Targets

0.39Weak

primary ciliary dyskinesiaOpen Targets

0.38Weak

atrial fibrillationOpen Targets

0.36Weak

atrial flutterOpen Targets

0.35Weak

male infertilityOpen Targets

0.31Weak

bronchiectasisOpen Targets

0.31Weak

Recurrent sinusitisOpen Targets

0.31Weak

situs inversusOpen Targets

0.31Weak

Situs inversus totalisOpen Targets

0.31Weak

Recurrent otitis mediaOpen Targets

0.30Weak

Abnormal thrombosisOpen Targets

0.28Weak

respiratory system diseaseOpen Targets

0.28Weak

primary ovarian insufficiencyOpen Targets

0.28Weak

allergic diseaseOpen Targets

0.28Weak

cardiac arrhythmiaOpen Targets

0.27Weak

osteoarthritisOpen Targets

0.26Weak

Alzheimer diseaseOpen Targets

0.26Weak

substance abuseOpen Targets

0.26Weak

attention deficit hyperactivity disorderOpen Targets

0.25Weak

smoking behaviorOpen Targets

0.23Weak

Ciliary dyskinesia, primary, 51UniProt

Pathogenic Variants2

NM_033656.4(BRWD1):c.656G>A (p.Arg219His)Likely pathogenic

Premature ovarian failure

★☆☆☆2020→ Residue 219

NM_033656.4(BRWD1):c.5573A>T (p.Gln1858Leu)Likely pathogenic

Male infertility;Recurrent otitis media;Situs inversus;Bronchiectasis;Recurrent sinusitis|Ciliary dyskinesia, primary, 51|Gastric cancer

☆☆☆☆2020→ Residue 1858

Tissue Expression6 tissues

Bone Marrow

100%

Brain

94%

Heart

65%

Ovary

64%

Liver

54%

Lung

48%

Gene Interaction Network6 neighbors

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Structure1 PDB hit

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PDB3Q2E · 1.74 Å · X-ray

View on RCSB

ConstraintgnomAD v4.1

LOEUFⓘ

0.45Moderately Constrained

pLIⓘ

1.00Intolerant

Observed/Expected LoF0.37 [0.30–0.45]

Rankings3 dim

Where BRWD1 stands among ~20K protein-coding genes

#8,398of 20,598
Most Researched53
#4,445of 5,509
Most Pathogenic Variants2
#2,482of 17,882
Most Constrained (LOEUF)0.45 · top quartile