TBX2 is a T-box transcription factor that primarily functions as a transcriptional repressor 12345. It binds to palindromic T-site DNA sequences in regulatory regions of target genes 2345. TBX2 is essential for cardiac atrioventricular canal formation and plays roles in limb pattern formation 6. The protein negatively modulates expression of critical developmental and cell cycle regulators including CDKN2A/p14ARF, CDH1/E-cadherin, and ADAM10 1345, and acts as a negative regulator of cellular senescence through PML inhibition 7. TBX2 promotes epithelial-mesenchymal transition 4 and participates in diverse developmental processes including branching morphogenesis and inner ear development, often functioning redundantly with TBX3. In disease contexts, TBX2 is amplified in BRCA1/2-associated breast cancers 89 and serves as a key driver transcription factor in coronary artery disease 10. In lung cancer, reduced TBX2 expression correlates with poor prognosis and increased promoter methylation 11. TBX2 is also identified as a marker of specialized lung aerocyte endothelial cells 12, and contributes to antiandrogen resistance in prostate cancer through chr17 dysregulation 13.