ZFPM2 encodes a zinc finger transcription cofactor essential for cardiac and gonadal development. As a member of the FOG (Friends of GATA) family, ZFPM2 functions as a critical heterodimeric partner with GATA transcription factors (GATA4, GATA5, GATA6), enabling both transcriptional activation and repression depending on cellular context 1. During cardiogenesis, ZFPM2 regulates genes necessary for heart morphogenesis and coronary vessel development from epicardium, while also participating in gonadal differentiation 1. Beyond protein-coding functions, a circular RNA derived from the ZFPM2 locus (circZFPM2) protects cardiomyocytes from hypertrophy-induced apoptosis and mitochondrial dysfunction, suggesting ZFPM2 locus products have multiple regulatory roles 2. ZFPM2 mutations cause conotruncal heart malformations, including tetralogy of Fallot and double outlet right ventricle, with missense variants identified in 1.5% of conotruncal defect patients 1. Additionally, ZFPM2 serves as a potential target in osteoporosis pathogenesis, regulated by miR-142-5p in osteogenic differentiation 3, and represents a candidate gene for nonobstructive azoospermia 4. The long non-coding RNA ZFPM2-AS1 has emerged as a dysregulated biomarker in multiple cancers and inflammatory conditions, though this represents a separate regulatory element rather than ZFPM2 protein function itself 5.