TCEAL3 (transcription elongation factor A like 3) is an X-linked transcriptional regulator involved in developmental and neurological processes. Primary function: TCEAL3 belongs to the Bex/Tceal transcriptional regulator family and is developmentally upregulated in retinal ganglion cells, where it suppresses axon regeneration after optic nerve injury 1. Mechanism: The protein modulates the mTOR pathway, which is critical for axonal regenerative capacity in central nervous system neurons 1. Disease relevance: TCEAL3 loss-of-function is associated with X-linked neurodevelopmental disorders; deletions encompassing TCEAL3 contribute to early-onset neurological disease characterized by hypotonia, intellectual disability, developmental delay, autistic-like behavior, and dysmorphic features 2. Clinical significance: TCEAL3 was identified as one of five discriminatory cyst fluid biomarkers (AUC >0.75) for stratifying malignant risk in intraductal papillary mucinous neoplasms of the pancreas; the combined five-protein model achieved 94% accuracy in distinguishing low-grade from high-grade/invasive lesions 3. These findings suggest TCEAL3 has dual roles in neurological development and potentially in pancreatic neoplasm progression, though further validation is needed for clinical application.