TCEAL4 (transcription elongation factor A like 4) is an X-linked gene encoding a protein with putative roles in transcriptional regulation through protein binding 1. In normal physiology, TCEAL4 expression is significantly upregulated during osteogenic differentiation of adipose-derived stem cells and is negatively correlated with stemness maintenance 1. TCEAL4 is expressed ubiquitously across normal human tissues 2. Functionally, TCEAL4 loss or haploinsufficiency contributes to neurological disease: heterozygous deletions in the Xq22.2 region encompassing TCEAL4 associate with early-onset neurological disease traits, and the closely related TCEAL1 gene loss-of-function causes X-linked dominant neurodevelopmental syndrome with hypotonia, developmental delay, intellectual disability, and autistic-like behavior 3. In cancer biology, TCEAL4 expression is down-regulated specifically in anaplastic thyroid cancer compared to normal thyroid tissue and differentiated thyroid cancers, suggesting potential loss of tumor suppressor function during malignant transformation 2. TCEAL4 was identified as a prognosis-related gene in lung adenocarcinoma risk prediction models 4. These findings indicate TCEAL4 functions in developmental processes and possesses potential tumor suppressive properties, though its precise molecular mechanism remains incompletely characterized.