TECTA (tectorin alpha) encodes a major non-collagenous structural component of the tectorial membrane, a critical extracellular matrix structure in the inner ear cochlea 1. The tectorial membrane covers the neuroepithelium and contacts the stereocilia bundles of sensory hair cells. Sound-induced movement of hair cells relative to the tectorial membrane deflects stereocilia, generating fluctuations in hair-cell membrane potential that transduce acoustic signals into electrical impulses 1. TECTA mutations cause both autosomal dominant (DFNA8/12) and recessive (DFNB21) non-syndromic hearing loss 2. In European populations, DFNA8/12 (TECTA) represents the second most common autosomal-dominant non-syndromic hearing loss form, accounting for 18% of elucidated cases 2. The c.3107G>A variant is particularly prevalent in Spain, causing progressive mid-to-high frequency sensorineural hearing loss with typical onset in childhood 3. Beyond non-syndromic deafness, rare TECTA variants are implicated in complex inner ear disorders: pathogenic variants were detected in 8.9% of age-related hearing loss cases versus <1% of controls 4, and TECTA mutations have been identified in familial Meniere's disease, suggesting involvement in stereocilia-tectorial membrane integrity 56. Most TECTA-related hearing loss patients benefit from hearing aids rather than requiring cochlear implants 3.