CCDC50 (coiled-coil domain containing 50) functions as a multifaceted autophagy receptor that plays critical roles in cellular homeostasis and disease pathogenesis. The protein serves as a lysophagy receptor, recognizing damaged lysosomes through galectin-3 and K63-linked polyubiquitination, then targeting them for autophagy-dependent degradation to maintain lysosomal integrity 1. Additionally, CCDC50 acts as an aggrephagy receptor, clearing polyubiquitinated protein aggregates to prevent cellular proteotoxicity, particularly in neuronal cells where it is highly expressed 2. The protein also participates in neuronal development, positively regulating neurite outgrowth through JNK/c-Jun pathway activation and interactions with nerve growth factor receptor signaling 3. CCDC50 demonstrates disease relevance across multiple conditions. It promotes tumor progression in melanoma and hepatocellular carcinoma, with high expression correlating with poor prognosis and metastasis 14. The protein controls NF-κB signaling and is required for survival in mantle cell lymphoma and chr3 lymphocytic leukemia 5. CCDC50 expression remains dysregulated even during clinical remission in psoriatic arthritis, suggesting ongoing pathophysiological involvement 6. These findings establish CCDC50 as a potential therapeutic target across cancer and inflammatory diseases.