TEKT1 encodes tektin-1, a microtubule-stabilizing protein that is a critical structural component of the axoneme in cilia and flagella 1. Tektin-1 localizes to centrosomes, basal bodies of primary and motile cilia, and the axonemal inner sheath, where it forms filamentous polymers that stabilize doublet microtubules and maintain ciliary motility 2. Loss of TEKT1 function causes microtubule instability and impaired ciliary motility 1. Clinically, TEKT1 mutations are associated with primary ciliary dyskinesia and motile ciliopathies, including Mainzer-Saldino syndrome 21. A zebrafish knockdown model confirmed TEKT1's role in ciliary motility, and genetic interactions between TEKT1 and WDR19 likely contribute to compound disease phenotypes 2. Beyond cilia biology, TEKT1 serves as a marker for germ cell differentiation and is expressed during spermatogenesis and embryonic stem cell differentiation into germ cells 34. Recent evidence suggests TEKT1 may have an oncogenic role in endometrial cancer through interactions with fatty acid metabolism pathways, promoting cell proliferation and migration 5.