TEKT2 (tektin 2) encodes a microtubule inner protein that is essential for sperm motility and ciliary function. The protein forms filamentous polymers in the walls of ciliary and flagellar microtubules and plays a key role in the assembly or attachment of inner dynein arms to microtubules in sperm flagella 1. TEKT2 expression is significantly associated with sperm motility, as demonstrated by reduced expression levels in cryopreserved sperm samples correlating with motility loss 1. The gene is consistently downregulated in male infertility conditions, particularly non-obstructive azoospermia, and has been identified as a hub gene in spermatogenesis through multiple bioinformatics analyses 23. Beyond reproductive function, TEKT2 shows unexpected roles in other cellular contexts, including involvement in diabetic nephropathy where it regulates podocyte cytoskeleton and correlates negatively with key podocyte markers 4. The gene is also implicated in ciliogenesis, as TEKT2 expression is transcriptionally regulated by TULP1 proteins and its downregulation contributes to ciliary defects in retinal degeneration 5. These findings establish TEKT2 as a critical structural component of microtubule-based motile structures with potential diagnostic and therapeutic implications in male infertility.