TENM2 (teneurin transmembrane protein 2) is a cell adhesion receptor that plays crucial roles in synaptic development and neuronal migration. TENM2 functions as a trans-synaptic signaling molecule that binds to latrophilin adhesion GPCRs and requires coincident binding with FLRT proteins to promote excitatory synapse formation in hippocampal neurons 1. During early brain development, TENM2-latrophilin interactions mediate contact repulsion-dependent mechanisms that guide cortical neuron migration 2. Beyond its neurological functions, TENM2 shows diverse physiological roles across different tissues. In kidney disease contexts, TENM2 expression correlates positively with estimated glomerular filtration rate and negatively with tubulointerstitial fibrosis, suggesting protective roles against diabetic kidney disease 3. TENM2 has been identified as a hub gene in acute kidney injury after transplantation 4. In metabolic regulation, TENM2 deficiency in human adipocyte precursors induces UCP1 expression and promotes brown adipocyte characteristics during differentiation 5. Clinical relevance includes associations with cancer progression, where TENM2 is targeted by miR-195-5p in head and neck squamous cell carcinoma 6, and potential involvement in lithium response mechanisms in bipolar disorder through differential methylation patterns 7.