TENT2 (terminal nucleotidyltransferase 2) is a cytoplasmic poly(A) RNA polymerase that selectively adds adenine nucleotides to the 3'-end of specific RNAs 1. Unlike canonical nuclear poly(A) polymerases, TENT2 only polyadenylates selected cytoplasmic mRNAs and does not participate in replication-dependent histone mRNA degradation 1. The enzyme plays crucial roles in microRNA regulation through monoadenylation, which stabilizes and prolongs the activity of specific miRNAs including miR-122 12. TENT2 functions through protein interactions, particularly with QKI-7, which recruits TENT2 to Argonaute 2 complexes for targeted miRNA adenylation 1. Beyond miRNA regulation, TENT2 participates in cellular RNA quality control by adenylating longer unadenylated RNAs produced by premature transcription termination 3. The enzyme also contributes to small noncoding RNA processing, promoting monoadenylation that affects RNA maturation versus degradation decisions 4. Clinically, TENT2 dysregulation has been observed in HPV-induced cancers, suggesting potential involvement in early cancer development 5. Additionally, TENT2 appears to have protective roles against pathological amyloid toxicity in neurodegenerative diseases 6.