HomeAboutRankingsData Sources
Β© 2026 GeneE
🧬
GeneE
1 sources retrieved Β· Most recent: April 2026 Β· Index updated 15 days ago
β“˜GeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
TIMM23B
translocase of inner mitochondrial membrane 23 homolog B
Chromosome 10 Β· 10q11.23
NCBI Gene: 100652748Ensembl: ENSG00000204152.15HGNC: HGNC:23581UniProt: Q5SRD1
38PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
FUNCTIONAL ROLE
Transporter
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
mitochondrionprotein import into mitochondrial matrixtransmembrane protein transporter activityTIM23 mitochondrial import inner membrane translocase complexneurodegenerative diseaseprostate carcinomaAlopecia universalishypotrichosis simplex
✦AI Summary

Based on limited published evidence, TIMM23B is a translocase component that may participate in translocation of transit peptide-containing proteins across the mitochondrial inner membrane as part of the PAM complex. TIMM23B functions in protein import into the mitochondrial matrix and likely serves as a transmembrane protein transporter within the TIM23 mitochondrial import inner membrane translocase complex 1. Expression of TIMM23B is regulated by the GABP transcription factor, suggesting its involvement in coordinating mitochondrial biogenesis with protein import capacity 1.

Sources cited
1
TIMM23B expression is regulated by GABP transcription factor; TIMM23B is a functional component of the TIM23 complex involved in preprotein translocation across mitochondrial inner membrane
PMID: 29413900
⚠Limited data available β€” This gene has 1 indexed publication. Summary and analysis may be incomplete.
Disease Associationsβ“˜20
neurodegenerative diseaseOpen Targets
0.33Weak
prostate carcinomaOpen Targets
0.10Weak
Alopecia universalisOpen Targets
0.05Suggestive
hypotrichosis simplexOpen Targets
0.04Suggestive
Trichodysplasia - xerodermaOpen Targets
0.03Suggestive
trichodysplasia-xeroderma syndromeOpen Targets
0.03Suggestive
alopecia universalis congenitaOpen Targets
0.03Suggestive
hypotrichosis 4Open Targets
0.03Suggestive
uncombable hair syndromeOpen Targets
0.03Suggestive
pure hair and nail ectodermal dysplasiaOpen Targets
0.03Suggestive
hypotrichosis 5Open Targets
0.03Suggestive
Clouston syndromeOpen Targets
0.03Suggestive
injuryOpen Targets
0.02Suggestive
Pick diseaseOpen Targets
0.00Suggestive
posterior cortical atrophyOpen Targets
0.00Suggestive
ulcerative colitisOpen Targets
0.00Suggestive
IGA glomerulonephritisOpen Targets
0.00Suggestive
Alzheimer diseaseOpen Targets
0.00Suggestive
progressive supranuclear palsyOpen Targets
0.00Suggestive
Parkinson diseaseOpen Targets
0.00Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
TOMM34Shared pathway100%HSPA9Protein interaction93%TIMM44Protein interaction93%TIMM10Protein interaction93%TIMM21Protein interaction93%PAM16Protein interaction93%
Tissue Expression6 tissues
Liver
100%
Brain
89%
Ovary
85%
Lung
75%
Heart
73%
Bone Marrow
72%
Gene Interaction Network
Click a node to explore
TIMM23BTOMM34HSPA9TIMM44TIMM10TIMM21PAM16
PROTEIN STRUCTURE
Preparing viewer…
AlphaFoldAI-predicted Β· UniProt Q5SRD1
View on AlphaFold β†—
Constraintβ“˜
LOEUFβ“˜
1.26LoF Tolerant
pLIβ“˜
0.00Tolerant
Observed/Expected LoF0.86 [0.60–1.26]
RankingsWhere TIMM23B stands among ~20K protein-coding genes
  • #10,555of 20,598
    Most Researched38
  • #13,272of 17,882
    Most Constrained (LOEUF)1.26
Genes detectedTIMM23B
Sources retrieved1 papers
Response timeβ€”
πŸ“„ Sources
1
1
Expression of the human TIMM23 and TIMM23B genes is regulated by the GABP transcription factor.
PMID: 29413900
Biochim Biophys Acta Gene Regul Mech Β· 2018
1.00