TMC5 (Transmembrane Channel-Like 5) is a probable ion channel component located in the plasma membrane, though its molecular function remains incompletely characterized 1. TMC5 demonstrates significant oncogenic properties across multiple cancer types, consistently showing upregulated expression in tumor tissues compared to normal tissues 23. The protein promotes cancer progression through multiple mechanisms, including regulation of epithelial-mesenchymal transition (EMT), cell cycle control, and metabolic pathways 41. In pancreatic adenocarcinoma, TMC5 overexpression correlates with advanced tumor stages and may be regulated by STAT3 transcription factor 3. Similarly, in hepatocellular carcinoma, TMC5 drives tumor progression by activating EMT-mediated invasion 4. The protein's expression is associated with poor prognosis across various cancers and correlates with immune cell infiltration patterns 25. TMC5's stability can be regulated through m6A RNA modifications by RBM15 in colon adenocarcinoma 6. Clinical significance extends to its potential as a diagnostic biomarker and therapeutic target, with high expression linked to chemotherapy resistance and stemness properties in gastric cancer 5. The protein also shows utility in forensic applications for human identification through RNA polymorphism analysis 7.