TMC3 (transmembrane channel-like 3) is a putative ion channel component with incompletely characterized molecular function 1. TMC3 exhibits mechanosensitive ion channel activity and localizes to the plasma membrane and cytosol 1. In cardiac fibroblasts, TMC3 is the most highly expressed member of the TMC protein family 1, suggesting specialized roles in mechanotransduction within cardiac tissue. TMC3 has emerging relevance in multiple disease contexts. In renal clear cell carcinoma, TMC3 expression significantly correlates with overall survival and positively associates with immune cell infiltration and checkpoint gene expression 2. In acute kidney injury, the TMC3-derived long non-coding RNA TMC3-AS1 negatively regulates IL-10 expression and promotes inflammatory pathways through miR-148a-3p regulation of Wnt5a, contributing to autophagy and pyroptosis 34. Notably, TMC3-AS1 silencing alleviates LPS-induced kidney injury 4. Genome-wide association studies identified TMC3 within a locus associated with longitudinal decline in lung function 5, with differential expression observed in COPD patients. Additionally, TMC3 transcription is altered in spinocerebellar ataxia type 3 mouse models 6, and TMC3 expression serves as a prognostic indicator in papillary thyroid cancer 7. The related family member TMC4 negatively regulates KCNQ1 potassium channels 8, suggesting TMC proteins may function as channel regulators.