TMC6 is a transmembrane regulatory protein with multiple cellular functions. In keratynocytes and lymphocytes, TMC6 forms a complex with its homolog TMC8 and the protein CIB1, where TMC6 stabilizes CIB1 and reciprocally regulates its activity 12. Additionally, TMC6 and TMC8 together activate the zinc transporter ZNT1 at the endoplasmic reticulum membrane, facilitating zinc uptake into the ER and downregulating zinc-induced transcription factors 3. In primary sensory neurons, TMC6 modulates thermal sensation by inhibiting M-channel (KCNQ2-KCNQ3) activity; TMC6 deletion increases M-channel function through elevated intracellular zinc, reducing heat hyperalgesia in chr17 pain models 4. Clinically, biallelic TMC6 mutations cause epidermodysplasia verruciformis (EV), an autosomal recessive disorder predisposing to persistent human papillomavirus (HPV) infection and cutaneous squamous cell carcinoma, particularly in UV-exposed regions 56. The TMC6-TMC8-CIB1 complex appears critical for immune control of βHPV rather than direct viral restriction 6. TMC6 variants also associate with psoriasis susceptibility 7 and cervical cancer risk 8, and genome-wide studies link TMC6-TMC8 to glycated hemoglobin levels 9.