2 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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19PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
protein bindingnuclear import signal receptor activityprotein import into nucleusmembranemitochondrial complex I deficiency, nuclear type 13mitochondrial complex I deficiencyneurodegenerative diseasegenetic disorder
Based on limited published evidence, TMCO6 is a transmembrane protein with coiled-coil domains that functions as a protein-binding receptor. The N-terminus of TMCO6 binds neutrophil extracellular trap (NET) DNA on CD8+ T cells, suppressing T-cell receptor signaling and NFκB p65 nuclear translocation to impair antitumor immunity in hepatocellular carcinoma 1. TMCO6 methylation patterns are associated with periodontal disease phenotypes in adult twins 2, suggesting broader immunological roles.
1
TMCO6 serves as a receptor for NET-DNA that impairs CD8+ T-cell immunity in HCC through suppression of TCR signaling and NFκB activation
PMID: 383815382
TMCO6 DNA methylation changes are associated with periodontal disease phenotypes including gingival bleeding and tooth mobility
PMID: 30760334⚠Limited data available — This gene has 2 indexed publications. Summary and analysis may be incomplete.
mitochondrial complex I deficiencyOpen Targets
mitochondrial complex I deficiency, nuclear type 13Open Targets
neurodegenerative diseaseOpen Targets
genetic disorderOpen Targets
diaphragm diseaseOpen Targets
hepatocellular carcinomaOpen Targets
systemic juvenile idiopathic arthritisOpen Targets
motor neuron diseaseOpen Targets
IGA glomerulonephritisOpen Targets
periodontal disorderOpen Targets
colorectal cancerOpen Targets
colorectal carcinomaOpen Targets
No pathogenic variants reported on ClinVar for this gene.