TMEM14A is a mitochondrial membrane protein that functions as a suppressor of apoptosis by stabilizing mitochondrial membrane potential and blocking the mitochondrial permeability transition 1. The protein inhibits the release of cytochrome c and downstream caspase-3 activation through a reactive oxygen species-independent mechanism 1. In cancer biology, TMEM14A promotes tumor progression across multiple malignancies. In non-small cell lung cancer (NSCLC), the receptor tyrosine kinase AXL transcriptionally upregulates TMEM14A expression to enhance cell proliferation, with elevated TMEM14A associated with poorer overall survival in lung adenocarcinoma patients 2. In ovarian cancer, TMEM14A knockdown reduces cell proliferation, suppresses invasion, and arrests the G1/S cell cycle transition by downregulating cyclin proteins and metastasis-related factors 3. TMEM14A also accelerates glycolytic metabolism and inhibits apoptosis in ovarian cancer cells 4. Notably, TMEM14A functions as a competing endogenous RNA hub, where circ_0003645 sponges miR-1179 to elevate TMEM14A expression and promote NSCLC progression 5. Beyond cancer, genetic variants affecting TMEM14A splicing (rs6924849) associate with mesial temporal lobe epilepsy with hippocampal sclerosis, where altered TMEM14A expression may contribute to neuronal loss 6. Additionally, TMEM14A variants relate to aromatase inhibitor-associated bone fractures through estrogen-dependent regulation 7.