TMEM187 (transmembrane protein 187) is an X-linked gene that appears to play important roles in immune regulation and autoimmune disease susceptibility. The protein is localized to cellular membranes and involved in transport vesicle functions based on GO annotations. TMEM187 demonstrates significant associations with multiple autoimmune conditions, particularly showing sex-specific effects in women. In celiac disease, variants in TMEM187 are associated with disease risk through regulation of gene expression in monocytes, with risk alleles correlating with decreased TMEM187 expression 1. The gene shows differential expression patterns between children and adults with celiac disease, being altered specifically in adults compared to controls 2. TMEM187 polymorphisms, particularly rs13397, are associated with rheumatoid arthritis susceptibility across multiple populations, with the major G allele conferring risk 34. The gene is also implicated in systemic lupus erythematosus risk through fine-mapping studies of the Xq28 locus 56. Additionally, TMEM187 variants have been identified in autism spectrum disorders, where the gene interacts with known ASD-associated genes including MECP2 7. The gene's involvement in osteoporosis has also been suggested through bioinformatics analyses 8.