TMEM87A (also known as GolpHCat) is a transmembrane protein with dual functional roles in mechanosensation and intracellular trafficking. Structurally, TMEM87A contains a GOLD domain positioned above a seven-transmembrane helix domain, forming part of the GOLD domain seven-transmembrane helix (GOST) protein family 1. As a mechanosensitive ion channel, TMEM87A contributes to touch sensation by generating mechanically activated currents in sensory neurons, with knockout mice showing touch insensitivity 2. The protein functions as a unique voltage-dependent cation channel localized to the Golgi apparatus, where it maintains Golgi pH homeostasis 3. Additionally, TMEM87A plays a critical role in retrograde transport from endosomes to the trans-Golgi network, supporting efficient post-Golgi anterograde transport of membrane proteins 4. Knockout studies reveal that TMEM87A deficiency causes fragmented Golgi morphology, altered protein glycosylation, and impaired hippocampus-dependent spatial memory 3. The protein's expression is modulated by inflammatory conditions, with TNF-α treatment altering its levels in periodontal ligament cells 5. These findings establish TMEM87A as a multifunctional protein essential for both cellular mechanotransduction and intracellular membrane trafficking.