TNFAIP8L3 (TNF alpha-induced protein 8 like 3) is a lipid transfer protein that shuttles phosphatidylinositol phosphates to the plasma membrane, enhancing PI3K-AKT and MEK-ERK signaling pathways 1. As a member of the TNFAIP8 family, it functions as a regulatory factor in immune response and tumorigenesis 1. In cancer pathology, TNFAIP8L3 expression correlates with aggressive disease progression. In lung adenocarcinoma, elevated TNFAIP8L3 expression associates with advanced T, N, and TNM stages, and independently predicts poor survival outcomes 2. In gastric cancer, TNFAIP8L3 promotes cell migration, with suppression by miR-9-5p acting as a tumor-suppressive mechanism 3. Conversely, in head and neck cancer, TNFAIP8L3 expression is reduced compared to normal tissues and correlates with pathological stage 4. In glioblastoma, elevated TNFAIP8L3 marks M1-phenotype myeloid cells in the peritumoral microenvironment 5. TNFAIP8L3 also appears in immune-related disease contexts; transcriptome analysis identified upregulated TNFAIP8L3 in idiopathic multicentric Castleman disease-TAFRO/NOS variants, suggesting roles in cytokine storm pathology 6. Genome-wide association studies identified TNFAIP8L3 as a candidate gene for corneal astigmatism 7, indicating broader physiological relevance beyond cancer and immunity.