TOMM22 encodes a central receptor component of the translocase of outer mitochondrial membrane (TOM) complex essential for importing nuclear-encoded mitochondrial proteins 1. The protein functions as a transit peptide receptor alongside TOMM20, facilitating the movement of preproteins into the translocation pore for proper mitochondrial protein import 1. TOMM22 is critical for maintaining mitochondrial function, dynamics, and morphology, with its knockdown impairing mitochondrial oxidative function, increasing superoxide production, and disrupting mitochondrial dynamics 2 3. In disease contexts, TOMM22 shows varied significance: it is overexpressed in pancreatic cancer where it promotes aggressive growth by enhancing mitochondrial protein import and respiratory function 1, and has been identified as a candidate gene for late-onset Parkinson's disease 4 5. The protein is specifically required for hepatocyte survival, with mutations causing liver-specific defects in zebrafish models 6. TOMM22 also plays roles in mitophagy regulation and has been implicated in intervertebral disc degeneration as a potential diagnostic biomarker 7. Statin-induced downregulation of TOMM22 contributes to mitochondrial dysfunction in skeletal muscle, potentially explaining statin-induced myopathy 2 3.