TOMM6 is a component of the translocase of the outer mitochondrial membrane (TOM) complex, essential for recognizing and translocating cytosolically synthesized preproteins into mitochondria 1. The TOM complex associates with ion channel VDAC2 and PINK1 kinase at depolarized mitochondria, stabilizing PINK1 at the outer mitochondrial membrane and triggering mitophagy through E3 ubiquitin ligase PRKN recruitment 1. This protein insertion function is critical for mitochondrial protein homeostasis and quality control. TOMM6 expression is dysregulated in disease contexts: it shows positive correlation with superoxide dismutase 1 (SOD1) in Kashin-Beck disease cartilage, suggesting altered mitochondrial function in this endemic arthritis 2. TOMM6 is among hub genes positively correlated with colorectal cancer development, identified through weighted gene co-expression network analysis, indicating potential involvement in cancer-associated metabolic reprogramming 3. Additionally, TOMM6 is upregulated in cisplatin-resistant lung adenocarcinoma cells, correlating with increased lncRNA UCA1 expression 4. These findings suggest TOMM6 dysfunction may contribute to disease pathogenesis through impaired mitochondrial protein import and altered cellular metabolism, representing a potential therapeutic target in cancer and degenerative diseases.