TP53I13 (tumor protein p53 inducible protein 13), also known as DSCP1, is a p53-inducible cytoplasmic protein with tumor suppressive properties. The gene is induced by genotoxic stress in a p53-dependent and p53-independent manner 1. Overexpression of TP53I13 inhibits tumor cell proliferation and retards cancer cell growth in vitro 1, 2. In gliomas, TP53I13 expression correlates with p53 signaling pathways, DNA replication, and the pentose phosphate pathway, and associates with immune cell infiltration including macrophages, neutrophils, and dendritic cells 2. High TP53I13 expression in glioblastomas and low-grade gliomas is associated with poor survival outcomes and represents an independent prognostic marker 2. TP53I13 has been identified as a potential driver mutation in carotid body tumors 3. Additionally, TP53I13 shows altered DNA methylation patterns in early Alzheimer's disease in the human hippocampus, suggesting potential roles beyond cancer 4. The lincRNA linc-TP53I13 is suppressed in adipose tissue of obese individuals and modulated during inflammatory responses 5, indicating involvement in cardiometabolic disease pathways.