TP73 encodes tumor protein p73, a member of the p53 family that regulates apoptosis and cell cycle control through complex isoform-dependent mechanisms 1. The gene produces multiple isoforms via alternative promoter usage and differential splicing, with TAp73 isoforms containing transactivation domains that promote apoptosis similar to p53, while ΔTAp73 isoforms lack these domains and act as anti-apoptotic factors that can inhibit both p53 and pro-apoptotic p73 functions 12. TP73 can activate p53-responsive genes and induce apoptosis in response to DNA damage and aberrant cell proliferation 2. Despite its pro-apoptotic activity in vitro, p73 knockout mice do not develop tumors, and primary human tumors often show wild-type p73 overexpression rather than loss-of-function mutations, suggesting TP73 may not function as a classical tumor suppressor 2. The gene's impact on tumorigenesis depends on the balance between tumor-promoting and tumor-suppressing isoforms 1. TP73 is located on chromosome 1, a region frequently deleted in various cancers 2. Additionally, the TP73 antisense RNA (TP73-AS1) is dysregulated in multiple cancer types and serves as a prognostic biomarker 3.