TRIB1 encodes a pseudokinase that functions as an adapter protein regulating protein degradation and cellular signaling pathways. The protein lacks kinase activity but serves as a scaffold to modulate substrate specificity of the COP1 ubiquitin ligase, particularly directing COP1 toward CEBPA degradation 1. TRIB1 regulates multiple cellular processes through its interactions with transcription factors and signaling molecules, including the MAPK pathway where it binds to MEK1 and other kinases to modulate their activity 1. In lipid metabolism, TRIB1 plays a crucial role in hepatic regulation, with genome-wide association studies identifying the TRIB1 locus as significantly associated with plasma lipid traits, coronary artery disease, and nonalcoholic fatty liver disease (NAFLD) 23. Mechanistically, TRIB1 degrades CEBPA through the EPAC/RAP2A pathway, contributing to β3-adrenergic receptor downregulation and catecholamine resistance in obesity 4. The protein also influences steroidogenesis by reducing progesterone synthesis through inhibition of mitochondrial biogenesis and downregulation of steroidogenic genes 5. Additionally, TRIB1 promotes M2 macrophage polarization via ERK/STAT3 signaling in inflammatory conditions like endometriosis 6. These diverse functions position TRIB1 as a central regulator of metabolic homeostasis and immune responses.