TRPM4 is a calcium-activated, non-selective cation channel that is impermeable to calcium but allows sodium and potassium influx upon activation 1. The channel is activated by increased intracellular calcium and regulated by temperature and PIP2, leading to membrane depolarization through sodium entry 1. TRPM4 is widely expressed throughout the body and plays crucial roles in cardiac conduction, with gain-of-function mutations causing familial cardiac conduction disorders 12. The channel exhibits temperature sensitivity, with activity dramatically potentiated by temperature increases 3. In pathological conditions, persistent TRPM4 activation can trigger necrotic cell death through sodium overload 4. TRPM4 physically couples with NMDA receptors, contributing to excitotoxicity in neurological conditions, and disrupting this interaction provides neuroprotection in stroke and retinal degeneration models 5. The channel is increasingly recognized in cancer biology, where overexpression contributes to proliferation, migration, and cell cycle progression in various cancers including prostate, colorectal, and B-cell lymphoma 67. TRPM4's role in disrupting calcium homeostasis makes it a potential therapeutic target for both neurological diseases and cancer metastasis 6.