TRPM7 is a ubiquitously expressed chanzyme—a fusion protein combining an ion channel and kinase domain—that functions as a critical regulator of divalent cation homeostasis and cellular signaling 1. As an ion channel, TRPM7 transports Mg2+, Ca2+, and Zn2+ across the plasma membrane, with particular prominence in magnesium homeostasis 2. The channel's kinase domain can be proteolytically cleaved from the channel segment in a cell-type-specific manner; in immune cells, caspase-mediated cleavage releases TRPM7-cleaved kinase fragments that translocate to the nucleus and phosphorylate histone residues involved in cell differentiation 3. TRPM7 participates in diverse pathophysiological processes including embryonic development, cardiovascular disease, and immunity 1. Recent evidence demonstrates TRPM7's involvement in pyroptosis during status epilepticus through a p-STAT3/TRPM7/Zn2+ positive feedback loop 4, and in rheumatoid arthritis-associated chondrocyte ferroptosis via the PKCα-NOX4 axis 5. In cancer, TRPM7 silencing shifts ovarian cancer metabolism from glycolysis to oxidative phosphorylation by enhancing AMPK activation and HIF-1α degradation 6. TRPM7 also mediates macrophage immunoregulation through mitochondrial transfer in testicular tissue homeostasis 7. These multifaceted roles position TRPM7 as a promising therapeutic target across neurological, inflammatory, and malignant diseases.