TRPM6 is a bifunctional protein comprising a TRP cation channel segment covalently linked to an α-type serine/threonine protein kinase 1. The channel primarily functions in magnesium homeostasis, facilitating transcellular Mg²⁺ absorption in the colon through TRPM6/7 complexes and apical Mg²⁺ uptake in the distal convoluted tubule of the kidney, where it is hormonally regulated by insulin and epidermal growth factor 2. TRPM6 is expressed in intestinal and renal epithelial cells and plays a central role in systemic Mg²⁺ homeostasis 1. Loss-of-function mutations in TRPM6 cause hypomagnesemia with secondary hypocalcemia (HSH), demonstrating its critical role in magnesium regulation 13. In contrast to human mutations, Trpm6 null mice show prenatal developmental delays, neural tube defects, and prenatal death, suggesting additional developmental functions 1. The channel belongs to the TRPM family of melastatin-related transient receptor potential channels, which are highly permeable to divalent cations including Ca²⁺, Mg²⁺, and Zn²⁺ 4. Clinically, TRPM6 mutations represent one of several hereditary forms of hypomagnesemia that have been identified 3.