TXNDC11 (thioredoxin domain containing 11) is an endoplasmic reticulum (ER) protein containing five thioredoxin-like domains that functions as a redox regulator in protein quality control. TXNDC11 expression is stress-inducible, regulated by the IRE1-sXBP1 pathway through conserved unfolded protein response elements 1. Mechanistically, TXNDC11 forms stable disulfide bonds with EDEM2 (through covalent linkage between specific cysteine residues), enabling the first mannose trimming step in glycoprotein ER-associated degradation (ERAD) 2. Additionally, TXNDC11 regulates expression and stability of ER stress sensors including ATF6α, CREB3, and CREB3L2 1. Clinically, elevated TXNDC11 expression correlates with poor prognosis in glioblastoma, serving as an independent prognostic factor 3. TXNDC11 knockdown inhibits glioma cell proliferation, migration, and invasion while enhancing apoptosis 3. Genetically, TXNDC11 harbors RNA modification-related SNPs associated with rheumatoid arthritis susceptibility 4, and variants near TXNDC11 influence plasma renin activity and blood pressure response to antihypertensive therapy 5. TXNDC11 also associates with lipid and metabolic trait regulation 6. These findings establish TXNDC11 as a multifunctional protein linking ER proteostasis, metabolic regulation, and disease pathogenesis.