TYRO3 is a receptor tyrosine kinase belonging to the TAM (TYRO3, AXL, MER) family that regulates tissue homeostasis and immune responses 1. TYRO3 functions as a pattern recognition receptor that binds phosphatidylserine (PtdSer) on apoptotic cell surfaces through bridging ligands Gas6 and Protein S, facilitating efferocytosis (apoptotic cell clearance) by macrophages 12. This process promotes M2-like macrophage polarization and immunosuppressive cytokine secretion, creating a pro-tumor microenvironment 1. TYRO3 also negatively regulates innate immune responses and limits type 2 immunity implicated in allergic sensitization 3. Disease relevance includes cancer therapy resistance, where high TYRO3 expression contributes to anti-PD-1/PD-L1 immunotherapy resistance by inhibiting tumor cell ferroptosis and reducing M1/M2 macrophage ratios 4. Additionally, TYRO3 genetic variants are associated with increased susceptibility to atopy and allergic rhinitis in Japanese populations, with risk alleles correlating to decreased TYRO3 mRNA expression 3. Clinically, TYRO3 represents a promising therapeutic target for cancer treatment and a potential predictive biomarker for immunotherapy response 4. The receptor also plays roles in bone homeostasis and represents an accessible target for various bone diseases 5.