UHMK1 (U2AF homology motif kinase 1) is a serine/threonine kinase containing a U2AF homology motif that functions in multiple cellular processes. As a splicing regulatory kinase, UHMK1 interacts with splicing factors SF1 and SF3B1 and phosphorylates over 117 proteins involved in spliceosome assembly and mRNA processing, affecting more than 270 alternative splicing events 1. In cell cycle regulation, UHMK1 phosphorylates CDKN1B/p27Kip1 to control G1 phase progression. Beyond splicing, UHMK1 functions as a potent oncogene across multiple cancer types. In colorectal cancer, UHMK1 promotes proliferation and chemoresistance through IL-6/STAT3 signaling via a positive feedback loop 2. In gastric cancer, UHMK1 enhances de novo purine synthesis by phosphorylating NCOA3, activating the ATF4 transcription factor 3. In lung adenocarcinoma, UHMK1 activates the PI3K/AKT/mTOR pathway 4, while in hepatocellular carcinoma, YAP-induced UHMK1 promotes MYBL2 nuclear enrichment and cell cycle gene expression 5. High UHMK1 expression in oral squamous cell carcinoma correlates with advanced TNM stage, lymph node metastasis, and poor survival 6. Genetically, UHMK1 variants show association with schizophrenia susceptibility 7, though expression levels appear unchanged in the disease 8.