UNC13C is a presynaptic protein essential for synaptic vesicle priming and exocytosis 1. It functions as a target of the diacylglycerol second messenger pathway and mediates calcium and phospholipid binding at the presynaptic active zone 1. The protein plays a regulatory role in synaptic transmission, particularly at parallel fiber-Purkinje cell and glutamatergic synapses 1. UNC13C has emerged as clinically significant in multiple disease contexts. It exhibits a neuroprotective role in Alzheimer's disease, though exome sequencing has identified potentially damaging variants in familial dementia cases 21. In cancer biology, UNC13C is aberrantly expressed and functions as an independent prognostic biomarker in hepatocellular carcinoma, correlating with tumor stage and overall survival 3. UNC13C expression is also dysregulated in oral squamous cell carcinoma, where it is regulated through the miR-96-5p/UNC13C axis and influences cell migration, invasion, and glycolysis 4. A genome-wide association study identified variants near UNC13C associated with breast cancer risk in African populations 5. Recent studies demonstrate that biallelic UNC13C variants cause severe neurodevelopmental impairment, with specific mutations affecting ethanol sensitivity through C1 domain alterations 6. These findings establish UNC13C as a multifunctional protein with implications for neurological and oncological disorders, potentially serving as a therapeutic target.