CADPS2 is a calcium-binding protein that mediates exocytosis of dense-core vesicles containing neurotransmitters and neuropeptides 1. It contains a C2 domain for calcium and phospholipid interactions and acts as a calcium sensor in vesicle trafficking 1. CADPS2 regulates neurotrophin release critical for neuronal development and function 2. Clinically, CADPS2 dysregulation is implicated in multiple neurodevelopmental and neurodegenerative conditions. Cadps2-knockout mice exhibit impaired brain-derived neurotrophic factor release and autistic-like behavioral phenotypes 2. Aberrant CADPS2 splicing (lacking exon 3) has been identified in autistic patients, affecting axonal protein distribution 2. Maternally inherited CADPS2 variants are associated with autism spectrum disorder and intellectual disability 3. In Parkinson's disease, CADPS2 expression is dysregulated: LRRK2 mutations increase expression while alpha-synuclein overexpression reduces it 4. A disease-specific neuronal cluster with CADPS2 overexpression and low tyrosine hydroxylase levels was identified exclusively in idiopathic Parkinson's disease midbrains 5. Additionally, a homozygous CADPS2 mutation (p.V559L) in the pleckstrin homology domain caused severe neurodegeneration with Lewy body-like pathology in parrots 6. CADPS2 mutations have also been identified in metastatic breast cancer as tumor-specific antigens 7.