UQCR11 encodes a component of mitochondrial complex III (ubiquinol-cytochrome c oxidoreductase) that participates in the electron transport chain and oxidative phosphorylation 12. The protein functions in electron transfer from ubiquinol to cytochrome c, contributing to ATP synthesis and cellular energy production 3. UQCR11 plays critical roles in cellular protection and metabolic regulation. In traumatic brain injury models, UQCR11 overexpression reduces oxidative stress and neuronal apoptosis, while improving motor function and memory recovery 4. The gene demonstrates neuroprotective effects through promoting neuron survival and inhibiting oxidative damage 4. In cardiovascular contexts, UQCR11 downregulation correlates with reduced cardiac function following myocardial infarction, where it appears to regulate immunometabolism 3. Clinically, UQCR11 deletions occur frequently in ovarian cancer, creating dependency on paralogue pathways that can be therapeutically targeted 1. The gene shows altered expression in various cancers, including lung adenocarcinoma and brain metastases, suggesting roles in cancer metabolism 25. UQCR11 expression is also regulated during cardiac regeneration and adipocyte differentiation, highlighting its importance in tissue remodeling and metabolic reprogramming 67.