USP17L18 — ubiquitin specific peptidase 17 like family member 18

5 sources retrieved · Most recent: April 2026 · Index updated 3 months ago

22PubMed Papers

#13,811 · top 71% of 19K genes

20Diseases

top 72%

0Drugs

0Pathogenic Variants

ProteaseExperimental GO EvidenceSwiss-Prot Reviewed

cysteine-type deubiquitinase activityregulation of protein stabilityregulation of apoptotic processnucleusimmunodeficiency 19combined immunodeficiency with skin granulomasimmunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemiagout

AI Summary

AI summary not yet available. Showing NCBI Gene summary.

ubiquitin specific peptidase 17 like family member 18

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.

Disease Associations20

immunodeficiency 19Open Targets

0.04Suggestive

combined immunodeficiency with skin granulomasOpen Targets

0.03Suggestive

immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemiaOpen Targets

0.03Suggestive

goutOpen Targets

0.03Suggestive

immunodeficiency 15aOpen Targets

0.03Suggestive

ring chromosome YOpen Targets

0.03Suggestive

X-Linked Combined Immunodeficiency DiseasesOpen Targets

0.03Suggestive

severe combined immunodeficiency due to LAT deficiencyOpen Targets

0.03Suggestive

obesity due to congenital leptin deficiencyOpen Targets

0.03Suggestive

immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopeniasOpen Targets

0.03Suggestive

immunodeficiency 105Open Targets

0.03Suggestive

Alymphoid cystic thymic dysgenesisOpen Targets

0.03Suggestive

obesity due to leptin receptor gene deficiencyOpen Targets

0.03Suggestive

immunodeficiency 112Open Targets

0.03Suggestive

common variable immunodeficiencyOpen Targets

0.03Suggestive

combined immunodeficiency due to ZAP70 deficiencyOpen Targets

0.03Suggestive

spermatogenic failure 84Open Targets

0.03Suggestive

spermatogenic failure 93Open Targets

0.03Suggestive

spermatogenic failure 65Open Targets

0.03Suggestive

immunodeficiency 18Open Targets

0.03Suggestive

Pathogenic Variants

No pathogenic variants reported on ClinVar for this gene.

Tissue Expression

No tissue expression data available for this gene.

Gene Interaction Network6 neighbors

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StructureAlphaFold

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AlphaFoldAI-predicted · UniProt D6R9N7

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Rankings1 dim

Where USP17L18 stands among ~20K protein-coding genes

#13,793of 20,598
Most Researched22