Based on limited published evidence, USP17L20 is a cysteine-type deubiquitinase that removes conjugated ubiquitin from target proteins. UniProt annotations indicate it regulates cell proliferation, cell cycle progression, apoptosis, cell migration, and viral response through protein deubiquitination in the cytosol and nucleus. A genome-scale CRISPR/Cas9 screening study identified USP17L20 as a candidate gene involved in cisplatin resistance in ovarian cancer 1, though further validation was not completed.