VAT1 (vesicle amine transport 1) is a multifunctional protein with enzymatic and transport activities that plays diverse roles in cellular processes and disease pathogenesis. The protein functions as a probable NADPH-dependent quinone oxidoreductase with unclear physiological substrates 1. Additionally, VAT1 mediates the transfer of negatively charged phospholipids including phosphatidic acid, phosphatidylserine, and phosphatidylglycerol between endoplasmic reticulum and mitochondrial membranes 23. The protein may regulate mitochondrial fusion through interactions with mitofusins 4. VAT1 has emerged as a significant biomarker in cancer biology, with high expression associated with poor prognosis in gastric cancer 5, hepatocellular carcinoma 6, and gliomas 7. In gastric cancer, VAT1 promotes cell proliferation, inhibits apoptosis, and regulates MAPK signaling and epithelial-mesenchymal transition 5. The protein contributes to immunosuppression in gliomas by negatively correlating with immune cell infiltration 7. VAT1 also functions as a catechin-binding protein, specifically interacting with epigallocatechin-3-gallate (EGCg) and potentially mediating some of its cellular effects 8. These diverse functions position VAT1 as both a potential therapeutic target and diagnostic biomarker in multiple diseases.