STARD7 (StAR-related lipid transfer domain containing 7) is a phosphatidylcholine-specific lipid transfer protein that transports phosphatidylcholine from the endoplasmic reticulum to mitochondria, facilitating mitochondrial membrane stabilization and respiration function 1. The protein localizes to the cytosol, mitochondrial intermembrane space, and outer mitochondrial membrane 2. STARD7 maintains critical physiological functions across multiple tissues. In intestinal epithelium, STARD7 preserves mitochondrial architecture and aerobic respiration; its loss impairs tight junction protein expression and barrier integrity, increasing susceptibility to inflammatory bowel disease 1. In skeletal muscle, STARD7 is essential for myogenic differentiation by maintaining mitochondrial phosphatidylcholine composition and supporting myomaker/myomerger expression 2. In trophoblast cells, STARD7 expression is synergistically regulated by SF-1 and β-catenin signaling 3. STARD7 expression is elevated in multiple cancer types (22 of 25 tumors analyzed), correlating with poor prognosis 4. In breast cancer, STARD7 loss triggers metabolic reprogramming with altered carnitine and SAM accumulation, causing epigenetic changes that arrest cell cycle progression 5. In colon cancer, SUMO1 degraders suppress STARD7 expression through TCF4 deSUMOylation, inducing ER stress and ROS accumulation 6. STARD7 repeat expansions are also associated with familial adult myoclonus epilepsy 7.